Telmisartan Research Paper

Abstract

Telsmartan (Telmisartan) is a research compound belonging to the class of angiotensin II receptor blockers (ARBs). It has been widely investigated for its potential role in regulating vascular resistance, improving endothelial function, and modulating metabolic processes. Studies indicate that Telmisartan exhibits both antihypertensive and metabolic regulatory properties, making it a molecule of interest in cardiovascular and metabolic research.
CAS Number: 144701-48-4

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Introduction

Telmisartan, chemically identified as 4′-[(1,4′-dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid, functions primarily as an angiotensin II type 1 (AT1) receptor antagonist. It prevents angiotensin II—a potent vasoconstrictor—from binding to its receptor, thereby reducing vascular resistance and promoting vasodilation.

Researchers have also observed that Telmisartan exhibits partial peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist activity, a mechanism relevant to glucose and lipid metabolism studies.

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Mechanism of Action

Telmisartan selectively blocks the AT1 receptor subtype, responsible for the cardiovascular effects of angiotensin II. By inhibiting this receptor, it promotes vasodilation, reduces aldosterone secretion, and decreases sodium reabsorption. The result is a reduction in vascular resistance in preclinical models.
Additionally, Telmisartan’s partial PPAR-γ activation may play a role in insulin sensitivity modulation and anti-inflammatory pathways, making it an intriguing molecule in the field of metabolic syndrome and cardiovascular health research.

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Pharmacokinetics (Research Overview)

• Absorption: High lipophilicity allows extensive tissue penetration.
• Half-Life: Approximately 24 hours in human-based models, allowing once-daily dosing.
• Elimination: Primarily biliary excretion.
• Protein Binding: >99%, mainly to albumin and α1-acid glycoprotein.

These pharmacokinetic properties make Telmisartan an excellent candidate for long-term receptor modulation studies in animal models.

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Scientific Research and Studies

Numerous studies have investigated Telmisartan for its cardiovascular, renal, and metabolic properties:

1. Cardiovascular Regulation
   • Study: Burnier M. et al. Journal of Hypertension, 2000.
     PubMed: 10953989
     • Demonstrated that Telmisartan effectively reduces blood pressure through long-lasting AT1 blockade.
2. Metabolic Regulation
   • Study: Benson SC. et al. Hypertension, 2004.
     PubMed: 15117912
     • Found that Telmisartan activates PPAR-γ, suggesting potential benefits in glucose metabolism regulation.
3. Endothelial Function
   • Study: Fogari R. et al. American Journal of Hypertension, 2003.
     PubMed: 12944015
     • Indicated improved endothelial reactivity compared to other ARBs.
4. Renal Protection Studies
   • Study: Musini VM. et al. Cochrane Database of Systematic Reviews, 2020.
     PubMed: 33242134
     • Discussed ARBs’ renoprotective role, with Telmisartan noted for long duration of action.

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Research Applications

Telmisartan is widely used in laboratory settings for:

• Cardiovascular physiology and receptor interaction studies
• Endothelial function and nitric oxide modulation
• Metabolic syndrome and insulin resistance models
• Renal function and oxidative stress research
• Pharmacokinetic and drug interaction studies

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Safety and Handling

This material is provided for laboratory research use only. It is not intended for human consumption, diagnostic, or therapeutic use. Researchers should handle all chemical compounds with appropriate safety equipment and procedures.

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SEO Keywords

Telmisartan research, Telsmartan, Telmisartan peptide, ARB receptor antagonist, Angiotensin II receptor blocker, cardiovascular research, metabolic studies, PPAR-γ activation, blood pressure research, CAS 144701-48-4, laboratory use only.

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10 Frequently Asked Questions (FAQ)

1. What is Telsmartan (Telmisartan)?
Telsmartan is an angiotensin II receptor blocker (ARB) researched for its effects on vascular resistance and metabolic modulation.

2. What is the CAS number of Telmisartan?
The CAS number is 144701-48-4.

3. What is the molecular formula of Telmisartan?
C₃₃H₃₀N₄O₂.

4. How does Telmisartan function in research settings?
It blocks AT1 receptors, helping to study vasodilation and metabolic pathways.

5. Is Telsmartan intended for human consumption?
No. It is for laboratory research use only.

6. What research fields commonly use Telmisartan?
Cardiovascular, renal, metabolic, and pharmacological modeling studies.

7. Does Telmisartan interact with PPAR-γ?
Yes, it has partial PPAR-γ agonist properties, making it of interest in metabolic research.

8. What are common forms of Telmisartan available for research?
It is typically available as a powdered compound for in vitro and in vivo testing.

9. How stable is Telmisartan under lab conditions?
It is stable at room temperature and should be stored in a cool, dry environment away from light.

10. Is Telsmartan an FDA-approved medication?
Telmisartan is an FDA-approved drug for human use under prescription brands, but Telsmartan, as supplied for research purposes, is not approved for human or veterinary use.

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References (PubMed)

1. https://pubmed.ncbi.nlm.nih.gov/10953989/
2. https://pubmed.ncbi.nlm.nih.gov/15117912/
3. https://pubmed.ncbi.nlm.nih.gov/12944015/
4. https://pubmed.ncbi.nlm.nih.gov/33242134/

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Disclaimer

This compound is intended for laboratory research purposes only.
It is not approved for human consumption, medical use, or diagnostic applications.
All research must be conducted by qualified professionals in controlled environments following institutional safety protocols.