For Research Use Only – Not for Human Consumption

Abstract

Sermorelin is a synthetic peptide analogue of the first 29 amino acids of growth hormone-releasing hormone (GHRH 1–29). It functions as a growth hormone secretagogue by stimulating the pituitary gland to release endogenous growth hormone (GH). Due to its role in mimicking natural GHRH activity, Sermorelin has been widely studied for endocrine regulation, aging research, and tissue repair models.

Introduction

Growth hormone-releasing hormone (GHRH) is essential in regulating the hypothalamic-pituitary-somatotropic (HPS) axis. Sermorelin acetate was developed as a short-chain synthetic peptide that retains the biological activity of native GHRH while improving stability.

Key distinctions of Sermorelin research compared to other GH secretagogues include:

• Direct pituitary stimulation (not ghrelin receptor mediated).
• A shorter half-life compared to long-acting analogs like CJC-1295.
• Use in controlled research of GH release patterns, IGF-1 production, and endocrine physiology.

Chemical Identification

• Compound Name: Sermorelin Acetate (GHRH 1–29 NH2)
• CAS Number: 86168-78-7
• Molecular Formula: C149H246N44O42S
• Molecular Weight: 3357.9 g/mol
• Classification: Synthetic growth hormone-releasing hormone (GHRH) analogue

Mechanism of Action in Research

Sermorelin binds to GHRH receptors on pituitary somatotrophs, leading to:

• Pulsatile release of growth hormone (mimicking natural secretion).
• Indirect stimulation of insulin-like growth factor-1 (IGF-1) via hepatic synthesis.
• Improved modeling of GH axis feedback regulation in laboratory settings.

Applications in Scientific Research

1. Endocrine Physiology – Examining hypothalamic-pituitary control of GH.
2. Aging Research – Evaluating GH decline in senescence.
3. Metabolism Studies – Investigating effects on protein, lipid, and glucose metabolism.
4. Tissue Repair Models – Exploring GH/IGF-1 roles in recovery processes.
5. Neuroendocrinology – Studying peptide signaling in GH regulation.

Safety & Compliance

Sermorelin is not FDA-approved for human or veterinary therapeutic use outside approved research environments. It is intended strictly for laboratory research purposes only. Appropriate safety measures must be applied when handling.

References (PubMed/NCBI Examples)

1. Walker RF, et al. “Stimulation of growth hormone secretion by a synthetic peptide corresponding to the amino-terminal segment of human growth hormone-releasing factor.” Endocrinology. 1984. [PubMed PMID: 6147319]
2. Thorner MO, et al. “Pharmacology of growth hormone-releasing hormone and its analogs.” Metabolism. 1990. [PubMed PMID: 2193267]
3. Khorram O, et al. “Age-related decline in growth hormone release: Stimulation with growth hormone-releasing hormone analogues.” J Clin Endocrinol Metab. 1997.

Disclaimer

This material is intended for laboratory research only. It is not for human consumption, medical treatment, veterinary use, or diagnostic purposes. Only trained professionals should handle in controlled environments.

Frequently Asked Questions (FAQ)

1. What is Sermorelin?
Sermorelin is a synthetic analogue of the first 29 amino acids of growth hormone-releasing hormone (GHRH 1–29).

2. What is the CAS number of Sermorelin?
CAS Number: 86168-78-7.

3. How does Sermorelin work in research?
It stimulates the pituitary gland to release growth hormone by binding to GHRH receptors.

4. What makes Sermorelin different from Ipamorelin?
Sermorelin acts via GHRH receptors, while Ipamorelin acts via ghrelin receptors (GHSR-1a).

5. What is the molecular weight of Sermorelin?
3357.9 g/mol.

6. What are the main research uses of Sermorelin?
Studies on GH physiology, metabolism, aging, and endocrine signaling.

7. Is Sermorelin FDA-approved for human use?
No. It is sold only for research purposes.

8. How is Sermorelin typically supplied?
As a lyophilized powder for laboratory reconstitution.

9. What is the difference between Sermorelin and CJC-1295?
Sermorelin has a shorter half-life, while CJC-1295 is modified for prolonged GH release.

10. Where can scientific studies on Sermorelin be found?
Peer-reviewed journals indexed on PubMed and NCBI databases.