For Research Use Only – Not for Human Consumption

Abstract

Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist widely studied for its ability to stimulate growth hormone (GH) release while exhibiting minimal activity on cortisol or prolactin. Unlike earlier GHS compounds, Ipamorelin has demonstrated high selectivity and reduced side effect profiles in preclinical research. This makes it a valuable tool for studying growth hormone regulation, metabolic function, and tissue recovery models in laboratory settings.

Introduction

Growth hormone secretagogues are synthetic compounds designed to mimic the action of ghrelin, a natural peptide that regulates GH release via the GHSR-1a receptor. Ipamorelin is considered a fifth-generation GHS, showing a more refined receptor selectivity compared to predecessors such as GHRP-2 and GHRP-6.

Researchers have studied Ipamorelin for its:

• Specificity for GH release.
• Minimal stimulation of ACTH and cortisol pathways.
• Potential use in controlled models of tissue regeneration, metabolism, and endocrine signaling.

Chemical Identification

• Compound Name: Ipamorelin (Impamorelin)
• CAS Number: 170851-70-4
• Molecular Formula: C38H49N9O5
• Molecular Weight: 711.86 g/mol
• Classification: Synthetic growth hormone secretagogue / Ghrelin receptor agonist

Mechanism of Action in Research

Ipamorelin binds selectively to the ghrelin receptor (GHSR-1a) on pituitary somatotroph cells, leading to GH release. Unlike other GHS compounds, Ipamorelin shows:

• High selectivity for GH stimulation.
• Low activity on prolactin and cortisol secretion.
• Pulsatile GH release, aligning more closely with natural physiological patterns.

Applications in Scientific Research

1. Endocrinology Research – Understanding GH/IGF-1 axis regulation.
2. Metabolism Studies – Investigating effects on lipid, glucose, and protein metabolism.
3. Tissue Repair Models – Studying GH influence on recovery and regeneration.
4. Aging Research – Exploring GH regulation in age-related endocrine decline.
5. Neuroendocrinology – Evaluating the signaling pathways of ghrelin receptor agonists.

Safety & Compliance

Ipamorelin is not FDA-approved for medical or dietary use. It is sold strictly for laboratory research purposes only. Proper laboratory safety protocols, including the use of protective equipment, must be followed.

References (PubMed/NCBI Examples)

1. Raun K, et al. “Ipamorelin, the first selective growth hormone secretagogue.” Eur J Endocrinol. 1998. [PubMed PMID: 9854170]
2. Svensson J, et al. “Effects of the growth hormone secretagogue ipamorelin in healthy subjects.” Eur J Endocrinol. 2000. [PubMed PMID: 10974639]
3. Veldhuis JD. “Neuroendocrine mechanisms of growth hormone regulation.” Endocrinol Metab Clin North Am. 2007.

Disclaimer

This product is intended for laboratory research only. It is not for human use, veterinary use, diagnostic purposes, or therapeutic application. All handling should be conducted by qualified professionals in a controlled research environment.

Frequently Asked Questions (FAQ)

1. What is Ipamorelin?
Ipamorelin is a synthetic peptide and selective ghrelin receptor agonist studied for its ability to stimulate growth hormone release.

2. What is the CAS number for Ipamorelin?
The CAS number is 170851-70-4.

3. How does Ipamorelin differ from other growth hormone secretagogues?
It is more selective, stimulating GH release without significantly affecting cortisol or prolactin.

4. What receptor does Ipamorelin act on?
It binds to the ghrelin receptor (GHSR-1a).

5. What is the molecular weight of Ipamorelin?
711.86 g/mol.

6. What are the main research applications of Ipamorelin?
Endocrinology, metabolism, aging, neuroendocrinology, and tissue repair studies.

7. Is Ipamorelin FDA-approved for clinical use?
No. It is not approved for human or veterinary use.

8. How is Ipamorelin usually supplied for research?
As a lyophilized peptide powder for reconstitution under laboratory conditions.

9. Does Ipamorelin increase cortisol levels?
Research shows Ipamorelin has minimal impact on cortisol secretion compared to earlier secretagogues.

10. Where can Ipamorelin studies be found?
Peer-reviewed journals and PubMed contain published studies on Ipamorelin and GH secretagogues.