For Research Use Only – Not for Human Consumption

Abstract

CJC-1295 No DAC and Ipamorelin are synthetic peptides widely studied for their effects on growth hormone regulation, cellular signaling, and metabolic processes. This research overview highlights their structural properties, receptor interactions, and areas of interest in preclinical research. Both peptides are of interest for investigating the endocrine system, peptide stability, and the modulation of growth hormone release without significant off-target activity.

Introduction

Peptides such as CJC-1295 No DAC and Ipamorelin are increasingly studied in laboratory environments to evaluate their role in cellular communication and endocrine modulation. These molecules are not approved for human consumption and remain restricted to controlled research use.

• CJC-1295 No DAC is a synthetic analog of growth hormone releasing hormone (GHRH) designed without the “drug affinity complex” modification, resulting in a shorter half-life compared to CJC-1295 with DAC.
• Ipamorelin is a selective ghrelin receptor agonist that demonstrates high specificity for growth hormone release with minimal interaction with cortisol or prolactin pathways.

Chemical Identification

• CJC-1295 No DAC
  • CAS Number: 863288-34-0
  • Molecular Formula: C152H252N44O42
  • Research Category: GHRH analog
• Ipamorelin
  • CAS Number: 170851-70-4
  • Molecular Formula: C38H49N9O5
  • Research Category: Growth hormone secretagogue

Mechanism of Action in Research

• CJC-1295 No DAC binds to the GHRH receptor, enhancing endogenous growth hormone release in a pulsatile manner, making it suitable for studies of short-term GH release dynamics.
• Ipamorelin interacts with ghrelin receptors (GHSR-1a), selectively stimulating growth hormone secretion without significantly impacting ACTH or cortisol levels.

Together, these peptides are often studied in combination for synergistic effects on GH signaling pathways.

Applications in Scientific Research

1. Endocrine Studies – Evaluation of pituitary and hypothalamic regulation.
2. Metabolic Research – Investigating growth hormone’s role in glucose, lipid, and protein metabolism.
3. Cellular Repair Models – Studying peptide influence on tissue recovery processes.
4. Aging Research – Assessment of peptide modulation in age-related hormone decline.

Safety & Compliance

These compounds are not approved by the FDA for medical or dietary use. They are restricted to laboratory research only. Handling requires compliance with institutional biosafety protocols.

References (PubMed/NCBI examples)

1. CJC-1295: Teichman SL et al. “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone.” J Clin Endocrinol Metab. 2006. [PubMed PMID: 16352683]
2. Ipamorelin: Raun K et al. “Ipamorelin, the first selective growth hormone secretagogue.” Eur J Endocrinol. 1998. [PubMed PMID: 9854170]
3. Veldhuis JD. “Neuroendocrine mechanisms of growth hormone regulation.” Endocrinol Metab Clin North Am. 2007.

Disclaimer

This material is supplied strictly for laboratory research use only. It is not intended for human consumption, veterinary use, or as a drug, food additive, or cosmetic. All research must be conducted by qualified professionals in a controlled laboratory environment.

Frequently Asked Questions (FAQ)

1. What is CJC-1295 No DAC?
CJC-1295 No DAC is a synthetic GHRH analog studied for short-duration stimulation of growth hormone release.

2. What is Ipamorelin?
Ipamorelin is a selective ghrelin receptor agonist that stimulates GH release with minimal effect on cortisol or prolactin.

3. Why combine CJC-1295 No DAC with Ipamorelin?
They are often studied together for potential synergistic effects on growth hormone pulsatility and amplitude.

4. What are their CAS numbers?
CJC-1295 No DAC: 863288-34-0; Ipamorelin: 170851-70-4.

5. Are these compounds FDA-approved for medical use?
No. They are not approved for medical, dietary, or human use.

6. What are the primary research applications?
Endocrine studies, metabolic regulation, and peptide signaling research.

7. How are these compounds supplied?
They are typically provided as lyophilized powders in sealed vials for controlled laboratory use.

8. Can these peptides be used in animals or humans?
No. They are for in vitro and laboratory research only.

9. What precautions are required when handling?
Researchers should follow biosafety protocols, wear PPE, and handle under sterile laboratory conditions.

10. Where can published research be found?
Studies are indexed in PubMed and NCBI databases under peptide hormone research.

NOT FOR HUMAN USE. FOR RESEARCH USE ONLY.