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Name: BAM-15
Chemical Name: N5,N6-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Molecular Formula: C₁₄H₈F₂N₆O
CAS Number: 1440290-99-7
BAM-15 is a mitochondrial protonophore uncoupler that promotes increased energy expenditure by dissipating the mitochondrial proton gradient without generating ATP, leading to enhanced metabolic rate (pubmed.ncbi.nlm.nih.gov).
Investigated in preclinical models for obesity, metabolic disorders, and mitochondrial dysfunction.
Oral dosing in rodents ranges from 5 to 15 mg/kg/day with effects on weight loss and improved glucose metabolism.
Oral administration is the primary method for in vivo studies.
Human oral pharmacokinetics are not established; all doses should be limited to preclinical research contexts.
Typical research oral doses: 10 mg or 15 mg per kg body weight per day in animal studies; human equivalent dose unknown and untested.
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