Introduction
Clomid (generic name: Clomiphene Citrate) is a selective estrogen receptor modulator (SERM) extensively used in research for its effects on fertility, endocrine regulation, and hormonal balance. Clinically, it is FDA-approved for treating certain cases of female infertility due to anovulation.
In a research-use setting, Clomid is studied for its ability to modulate estrogen receptors and thereby influence luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release.
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Mechanism of Action
- Estrogen receptor blockade: Clomid binds to estrogen receptors in the hypothalamus, preventing estrogen from exerting negative feedback.
- Hormone stimulation: This blockade increases gonadotropin-releasing hormone (GnRH) release, leading to elevated LH and FSH.
- Testosterone & Ovulation: In models, this stimulates ovarian follicle development (in females) or testosterone production (in males).
Research Applications
- Fertility Studies – Investigating ovulation induction and reproductive biology.
- Endocrine Pathway Models – Understanding hypothalamic-pituitary-gonadal (HPG) axis regulation.
- Male Hormone Research – Studying testosterone stimulation via LH/FSH elevation.
- Breast Cancer Models – Examining SERM effects on estrogen-driven cell growth.
- Post-Cycle Hormone Studies – Analyzing hormonal recovery mechanisms.
Safety and Compliance
- FDA-approved indication: Clomiphene Citrate is approved for use in treating infertility in women.
- Research-use disclaimer: Any Clomid compound supplied for research is NOT FOR HUMAN CONSUMPTION.
- Compliance: All laboratory studies must adhere to institutional and federal guidelines.
PubMed Research References
- Kousta E, White DM, Franks S. Modern use of clomiphene citrate in induction of ovulation. Hum Reprod Update. 1997;3(4):359–365. PubMed PMID: 9459266
- Homburg R. Clomiphene citrate—end of an era? A mini-review. Hum Reprod. 2005;20(8):2043–2051. PubMed PMID: 15878921
- Casper RF, Yen SS. Induction of ovulation with clomiphene citrate. Fertil Steril. 1979;31(1):1–8. PubMed PMID: 366168
- Taylor AE, et al. Clomiphene citrate effects on pituitary and ovarian function. J Clin Endocrinol Metab. 1994;79(4):1212–1216. PubMed PMID: 7962312
FAQ (Frequently Asked Questions)
1. What is Clomid used for in research?
It is studied for ovulation induction, fertility pathways, and endocrine regulation.
2. How does Clomid differ from Arimidex or Nolvadex?
Clomid is a SERM, while Arimidex is an aromatase inhibitor and Nolvadex another SERM with differing receptor actions.
3. Is Clomid FDA-approved?
Yes, for infertility treatment in women. Research-use Clomid is not for human use.
4. How does Clomid stimulate testosterone in male research models?
By blocking estrogen feedback, Clomid increases LH and FSH, which stimulate testicular testosterone production.
5. Can Clomid cause side effects in clinical contexts?
Yes — hot flashes, visual disturbances, mood changes, and ovarian enlargement have been documented.
6. How long has Clomid been researched?
Since the 1960s, making it one of the most widely studied fertility drugs.
7. Is Clomid used in breast cancer research?
Yes, as a SERM, it is studied in hormone receptor-positive breast cancer models.
8. Does Clomid work in men and women?
Yes — it stimulates ovulation in women and testosterone production in men in experimental settings.
9. Is Clomid safe for long-term use?
Extended use is associated with risks such as ovarian cysts and reduced efficacy.
10. Where can I find more studies?
Visit PubMed Clomid Research.
⚠️ Disclaimer:
Combat Research compounds are sold for laboratory research purposes only. Not for human consumption, diagnostic, or therapeutic use.
