Combat Research – BAM-15 Research Paper

Introduction

BAM-15 is a mitochondrial uncoupling agent being studied in research for its effects on energy metabolism, obesity, and oxidative stress. It acts by disrupting the proton gradient across the mitochondrial inner membrane, leading to increased energy expenditure and reduced fat accumulation in preclinical models.

Unlike stimulants or hormones, BAM-15 works at the mitochondrial level, making it a unique compound for metabolic disease and obesity research.

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Mechanism of Action

• Mitochondrial uncoupling: BAM-15 transports protons across the mitochondrial inner membrane, dissipating the proton gradient.
• Increased energy expenditure: Causes mitochondria to burn more fuel (fat and glucose) without producing proportional ATP.
• Reduced ROS production: By lowering mitochondrial membrane potential, BAM-15 reduces reactive oxygen species (ROS) generation.
• Weight regulation potential: Shown in animal models to reduce fat mass without reducing food intake.

Research Applications

1. Obesity and Metabolic Research – Studying energy expenditure and fat metabolism.
2. Type 2 Diabetes Models – Exploring improvements in insulin sensitivity.
3. Aging and Longevity – Investigating mitochondrial health and ROS regulation.
4. Cardiometabolic Disease – Understanding energy balance in cardiovascular models.
5. Liver & Muscle Research – Assessing mitochondrial function in metabolic tissues.

Safety and Compliance

• Clinical status: BAM-15 is not FDA-approved and remains an experimental research chemical.
• Research-use disclaimer: For laboratory research purposes only. Not for human consumption.
• Safety considerations: Mitochondrial uncouplers can cause profound metabolic changes; handling requires strict laboratory protocols.

PubMed Research References

1. Alexopoulos SJ, et al. Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun. 2020;11:2397. PubMed PMID: 32424346
2. Parker N, et al. BAM15, a novel mitochondrial uncoupler, reduces oxidative stress and improves metabolism in mice. J Biol Chem. 2020;295(40):13712–13726. PubMed PMID: 32699016
3. Alexopoulos SJ, et al. Targeting mitochondria with BAM15 improves metabolic health. Cell Metab. 2020;32(6):971–987. PubMed PMID: 33357413

FAQ (Frequently Asked Questions)

1. What is BAM-15 used for in research?
It is studied for its role in mitochondrial uncoupling, energy metabolism, and obesity reduction.

2. How does BAM-15 differ from traditional weight loss compounds?
It increases energy expenditure at the mitochondrial level without acting as a stimulant.

3. Is BAM-15 FDA-approved?
No, BAM-15 is not FDA-approved. It is strictly a research compound.

4. Can BAM-15 improve insulin sensitivity?
Yes, studies in mice show enhanced glucose control and insulin sensitivity.

5. Does BAM-15 reduce food intake?
No, BAM-15 reduces fat mass in models without decreasing appetite.

6. How does BAM-15 affect ROS (reactive oxygen species)?
It lowers mitochondrial membrane potential, reducing ROS production.

7. Is BAM-15 safe for human use?
No, BAM-15 is not approved for human use. Research suggests potential but also risks.

8. Can BAM-15 increase lifespan in models?
Studies suggest it may improve mitochondrial function, which is linked to longevity, but more research is needed.

9. How is BAM-15 administered in research?
Animal studies use oral or injected formulations under controlled laboratory conditions.

10. Where can I find BAM-15 research?
PubMed has peer-reviewed studies: BAM-15 Research.

⚠️ Disclaimer:
Combat Research compounds are provided for laboratory research purposes only. Not for human consumption, diagnostic, or therapeutic use.