MK-677
MK-677 (Ibutamoren / Nutrobal) — Research Overview Abstract MK-677 (Ibutamoren, commonly marketed as Nutrobal) is an orally active, non-peptide ghrelin receptor (GHS-R1a) agonist and growth-hormone secretagogue. It stimulates pulsatile growth hormone (GH) release and increases circulating insulin-like growth factor-1 (IGF-1) in humans and animals. Because of its oral bioavailability and prolonged GH-releasing effects without activation […]
MK-777
Chemical Identity & Known Information Mechanism of Action & Comparison with MK-677 MK-677 (Ibutamoren) – Brief Background MK-777 – What’s Different (Claims) Key Differences Summary Feature MK-677 MK-777 (claims) Human clinical data Yes Very limited or none Appetite / hunger effect Known to increase appetite in many Claimed to be reduced vs MK-677 Impactful Aesthetics […]
Levothyroxine Sodium (T4) — Research Overview
Abstract Levothyroxine (T4) is a synthetic form of the endogenous thyroid hormone thyroxine, responsible for regulating metabolism, energy production, and cellular growth. It is commonly studied in endocrine, metabolic, and mitochondrial research to explore the effects of thyroid hormone modulation on lipid metabolism, protein synthesis, and basal metabolic rate.Although approved clinically for hypothyroidism, the research-grade […]
Clenbuterol Hydrochloride (Clen) — Research Overview
Abstract Clenbuterol Hydrochloride (Clen) is a β₂-adrenergic receptor agonist primarily developed as a bronchodilator for respiratory disorders such as asthma. In scientific and preclinical settings, it has been studied for its effects on metabolic rate, thermogenesis, and skeletal muscle preservation.Although not approved for human use in the United States for metabolic or performance enhancement, Clenbuterol […]
Injectable SR9009 (Stenabolic) — Research Paper
Abstract SR9009 (Stenabolic) is a synthetic Rev-Erbα/β agonist developed to study circadian rhythm regulation, mitochondrial biogenesis, and lipid/glucose metabolism in preclinical models. Injectable SR9009 formulations allow for improved bioavailability and pharmacokinetic stability compared to oral routes, which have shown limited absorption in prior studies.Preclinical research suggests SR9009 may enhance energy expenditure, fatty-acid oxidation, and endurance […]
Combining Cardarine (GW-501516) and SLU-PP-332 — Research paper
Abstract Cardarine (GW-501516), a potent PPARδ (PPARβ/δ) agonist, and SLU-PP-332, a pan-ERR (estrogen-related receptor) agonist with high potency at ERRα, each activate complementary metabolic programs that increase fatty-acid oxidation, mitochondrial function, and endurance-like phenotypes in animal models. Preclinical evidence suggests the two drug classes could be mechanistically complementary: PPARδ activation shifts substrate use toward lipids […]
Oral BPC-157 (Body Protection Compound-157) — Research Paper
Abstract BPC-157 (pentadecapeptide BPC-157; sequence: Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val) is a gastric-derived 15-mer peptide that has attracted preclinical interest for cytoprotective, angiogenic, anti-inflammatory, and tissue-repair activities. Unlike many short peptides, BPC-157 shows remarkable stability in gastric juice and has demonstrated efficacy when given orally in multiple animal models (gastrointestinal injury, colitis, tendon and muscle healing, and others). This […]
Oral KPV (Lys-Pro-Val) — Research Paper
Abstract KPV (Lys-Pro-Val; also described as α-MSH(11–13)) is a melanocortin-derived tripeptide with reproducible anti-inflammatory and tissue-protective effects in vitro and in vivo. Importantly for gastrointestinal applications, KPV can be transported across intestinal epithelia via the proton-coupled oligopeptide transporter PepT1, enabling oral administration to reduce inflammation in models of colitis. Recent work has focused on improving […]
GHK-Cu (Copper Tripeptide-1) — Research Paper
Abstract GHK-Cu (glycyl-L-histidyl-L-lysine complexed with Cu²⁺), often listed in cosmetics as Copper tripeptide-1, is a naturally occurring tripeptide-metal complex with documented roles in tissue remodeling, wound healing, anti-inflammatory activity, and skin regeneration. Preclinical and clinical reports indicate GHK-Cu stimulates collagen and glycosaminoglycan synthesis, modulates gene expression related to tissue repair, and shows activity in hair […]
Telmisartan Research Paper
Abstract Telsmartan (Telmisartan) is a research compound belonging to the class of angiotensin II receptor blockers (ARBs). It has been widely investigated for its potential role in regulating vascular resistance, improving endothelial function, and modulating metabolic processes. Studies indicate that Telmisartan exhibits both antihypertensive and metabolic regulatory properties, making it a molecule of interest in […]