🧪 TB-500 (Thymosin Beta-4 Acetate) — Research Peptide

CAS Number: 77591-33-4
Synonyms: Thymosin β4, TB4, Thymosin Beta-4 Acetate, TMSB4X Peptide
Molecular Formula: C₂₂₁H₆₇₇N₁₈₉O₅₅S₂
Molecular Weight: ≈ 4,928 Da

🔬 Overview

TB-500 (Thymosin Beta-4 Acetate) is a synthetic peptide fragment modeled after a naturally occurring protein, Thymosin Beta-4, found in most mammalian cells. It is categorized as a research-grade peptide and is not approved by the U.S. Food and Drug Administration (FDA) for human or veterinary use.

This compound is distributed strictly for laboratory, in vitro, or animal research applications — not for diagnostic, therapeutic, or consumer use.

⚗️ Chemical & Physical Properties

📘 Research Context (Preclinical Literature)

Note: All findings below are derived from preclinical or animal studies. None of these data should be interpreted as evidence of safety or efficacy in humans.

• Tissue regeneration & repair: Preclinical data suggest TB-500 may play a role in angiogenesis, cell migration, and cytoskeletal organization via upregulation of actin polymerization.
  – PubMed: 16697475

• Cardiac and muscle studies: Animal models indicate potential benefits in myocardial tissue recovery following injury.
  – PubMed: 19395502

• Wound and corneal repair research: TB-500 has been explored for cell migration and epithelial repair mechanisms.
  – PubMed: 22136499

⚠️ These findings are not evaluated or approved by the FDA for human use.

⚠️ Regulatory & Compliance Statement

• For Research Use Only.

• Not for Human Consumption or Injection.

• Not an FDA-approved drug, cosmetic, or supplement.

• Intended solely for in vitro, laboratory, or animal model research.

• No claims are made regarding safety, efficacy, or health outcomes.

🧴 Recommended Label Example (Compliant Text)

Product: TB-500 (Thymosin Beta-4 Acetate)
CAS: 77591-33-4
Purity: ≥98% (HPLC)
Form: Lyophilized powder
Intended Use: For scientific research use only. Not for human use.
Storage: Store at –20 °C. Avoid repeated freeze-thaw cycles.

📚 Suggested Reference List (for “Further Reading”)

1. Huff T. et al. (2001). Thymosin β4 is a G-actin sequestering protein involved in motility and cell migration. PNAS, 98(19): 10317–10322. PubMed: 11517310

2. Bock-Marquette I. et al. (2004). Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and repair. Nature, 432(7016): 466–472. PubMed: 15565145

3. Sosne G. et al. (2015). Thymosin beta 4 promotes corneal epithelial cell migration and wound healing. Invest Ophthalmol Vis Sci, 56(1): 144–153. PubMed: 25535818