LGD-4033 (Ligandrol) – Selective Androgen Receptor Modulator (SARM) | ≥99% Purity

CAS Number: 1165910-22-4
Molecular Formula: C₁₄H₁₂F₆N₂O
Molecular Weight: 338.24 g/mol
Synonyms: Ligandrol, VK5211, LGD4033
Form: Fine crystalline powder
Purity: ≥99% (confirmed by HPLC)

For Research Use Only

This product is strictly intended for preclinical research. It is not approved by the FDA for human consumption, medical use, or veterinary application. Use is restricted to qualified research personnel within licensed laboratories.

Product Overview

LGD-4033 (Ligandrol) is a potent, non-steroidal Selective Androgen Receptor Modulator (SARM) developed to target androgen receptors in muscle and bone tissues with high affinity and selectivity. As a second-generation SARM, LGD-4033 is currently being investigated in various non-clinical and early-phase clinical studies for its anabolic potential in treating muscle wasting, sarcopenia, and osteoporosis—without the common adverse effects seen with anabolic steroids.

CombatResearch.io provides LGD-4033 at ≥99% purity, rigorously tested for identity, potency, and impurity profile. Our compound is ideal for in vitro studies and animal model research in the areas of androgen receptor function, skeletal muscle physiology, and bone metabolism.

Scientific Research Applications

• Androgen receptor binding affinity studies

• Lean muscle mass augmentation modeling

• Sarcopenia and cachexia (muscle wasting) research

• Bone density and osteoanabolic signaling pathways

• Preclinical pharmacokinetics and SAR analysis

• Non-steroidal anabolic therapy investigations

Pharmacological Profile

• Receptor Selectivity: High selectivity for androgen receptors in skeletal muscle and bone tissue

• Mechanism: Modulates gene expression to promote anabolic activity while minimizing androgenic side effects

• Half-life (in clinical trials): ~24–36 hours (supporting once-daily administration in models)

• Oral Bioavailability: High, making it suitable for oral or systemic administration in research models

Product Specifications

• Appearance: White to off-white crystalline powder

• Solubility: Soluble in DMSO, ethanol; limited aqueous solubility

• Storage Instructions:

  • Store at 2–8°C, in a sealed, moisture-proof container

  • Protect from light, heat, and humidity

  • Use desiccant if storing long-term

Handling Precautions:

• Use appropriate PPE (gloves, lab coat, eye protection)

• Apply aseptic technique to prevent contamination

• Dispose according to institutional chemical waste protocols

Regulatory & Safety Statement

⚠️ For Laboratory Research Use Only

• Not for human or veterinary use

• Not approved by the U.S. FDA, EMA, or other regulatory agencies

• May not be used as a drug, food, dietary supplement, or cosmetic ingredient

• Researchers must comply with all applicable local, state, and federal regulations when using this compound

Scientific References & Research Citations

• Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator LGD-4033 increases lean body mass and improves physical function in healthy adults. J Gerontol A Biol Sci Med Sci. 2015;70(1):87–95.

• Basaria S, et al. Selective androgen receptor modulators in the treatment of osteoporosis and sarcopenia. Curr Osteoporos Rep. 2019.

• Srinath R, Dobs A. Clinical trials with SARMs: Status and prospects. Curr Opin Endocrinol Diabetes Obes. 2014.

For full literature support, visit: clinicaltrials.gov (Search: “LGD-4033” or “VK5211”)

CombatResearch.io Quality Commitment

At CombatResearch.io, all compounds are produced under strict quality control standards and are accompanied by a Certificate of Analysis (COA). Each batch undergoes HPLC, NMR, and mass spectrometry testing to ensure identity and purity suitable for advanced experimental protocols.