🔬 1,3‑Dimethylamylamine (DMMA / DMAA) – For Research Use Only

Chemical Identity

• Synonyms: 1,3‑Dimethylamylamine (DMAA), Methylhexanamine, Geranamine, Methylhexaneamine

• IUPAC Name: 4‑Methylhexan‑2‑amine

• CAS Number: 105‑41‑9

• Molecular Formula: C₇H₁₇N

• Appearance: White crystalline powder or hydrochloride salt, research‑grade

Pharmacology & History
Originally developed as an inhaled nasal decongestant by Eli Lilly in the 1940s and marketed until the 1980s, DMMA later emerged in the 2000s as a “stimulant” in sports‑performance and weight‑loss supplements webmd.com+15en.wikipedia.org+15mja.com.au+15supplemented.co.uk+8fda.gov+8en.wikipedia.org+8. It acts as a central nervous system sympathomimetic, enhancing norepinephrine release, resulting in vasoconstriction and increased heart rate, similar to ephedrine and amphetamines .

Legal & Regulatory Status

• USA: Considered an unsafe food additive—not a legal dietary supplement ingredient—making its inclusion in supplements illegal supplemented.co.uk+10fda.gov+10reddit.com+10.

• Global: Banned or regulated in numerous jurisdictions, including Australia (Schedule 10), New Zealand, Canada, and under WADA for athletic use app.mrsupplement.com.au.

• FDA Actions: Since 2012, multiple warning letters issued; major brands like Jack3d and OxyElite Pro were removed or seized journalejnfs.com+9fda.gov+9info.gov.hk+9.

Safety Profile & Adverse Effects

• The FDA warns that DMMA may elevate blood pressure and lead to serious cardiovascular events, including arrhythmias, chest tightness, heart attack, stroke, seizures, and neurological issues supplemented.co.uk+10fda.gov+10info.gov.hk+10.

• Case reports and medical literature detail serious adverse events such as cerebral hemorrhage, cardiomyopathy, toxic liver injury, and death info.gov.hk+14mja.com.au+14en.wikipedia.org+14.

• A controlled 10-week trial noted a ~6 mmHg systolic BP increase, slight heart rate changes, and minor metabolic changes pmc.ncbi.nlm.nih.gov.

Research Use Only

• Not for human or veterinary use, diagnosis, treatment, or prevention of disease.

• Only to be handled by qualified personnel in controlled laboratory environments.

• Proper labeling as “Not for human use” is mandatory under U.S. regulations.

Handling & Storage

• Store sealed, cool, and dry—recommended at 2–8 °C or room temperature (20–25 °C).

• Use standard lab PPE (gloves, lab coat, goggles).

• Dispose of according to institutional chemical and controlled‑substance protocols.