🔬 SR9009 (Stenabolic) – For Research Use Only

Chemical Identity

• Name: SR9009, also known as Stenabolic

• IUPAC Name: Ethyl 3‑[[(4‑chlorophenyl)methyl][(5‑nitro‑2‑thienyl)methyl]amino]methyl‑1‑pyrrolidine‑carboxylate

• CAS Number: 1379686‑30‑2 pubmed.ncbi.nlm.nih.gov+15tocris.com+15targetmol.com+15en.wikipedia.org+1targetmol.com+1

• Molecular Formula: C₂₀H₂₄ClN₃O₄S, MW ≈ 438 g/mol tocris.com

Mechanism of Action
A synthetic agonist of nuclear receptors Rev‑Erbα/β, with an IC₅₀ of ~670 nM for α and ~800 nM for β reddit.com+15tocris.com+15en.wikipedia.org+15. It alters circadian gene expression (e.g., BMAL1, CLOCK) and metabolism in animal studies pubmed.ncbi.nlm.nih.gov+15tocris.com+15targetmol.com+15.

Research Applications

• Modulation of circadian rhythm and metabolic studies

• Shown to reduce weight gain and improve insulin sensitivity in mice exposed to constant light (10 mg/kg/day) pubmed.ncbi.nlm.nih.gov+1tocris.com+1

• Explored for neuroprotective roles post‑ischemic injury thno.org+15frontiersin.org+15ncbi.nlm.nih.gov+15

• Investigated in cancer models, e.g., small-cell lung cancer tga.gov.au+7thno.org+7pubmed.ncbi.nlm.nih.gov+7

Form & Purity

• Supplied as ≥98% HPLC-purity powder tocris.com

• Typically dissolved for intraperitoneal injection (e.g., 100 mg/kg/day in mice)

⚠️ Regulatory & Safety Notice

• Not approved by FDA for human or veterinary use; strictly for laboratory research.

• On the World Anti‑Doping Agency (WADA) prohibited list as a metabolic modulator en.wikipedia.org.

• Contains nitrothiophene substructures that may produce off-target or toxic effects reddit.com.

• May also exert effects independent of Rev‑Erb, necessitating careful mechanistic controls reddit.com+15reddit.com+15pubmed.ncbi.nlm.nih.gov+15.

🧪 Practical Handling & Storage

• Store at +4 °C, protected from light reddit.com+15tocris.com+15thno.org+15.

• Reconstitute in appropriate solvent (e.g., DMSO, ethanol, propylene glycol) under sterile conditions.

• Use gloves, lab coat, and eye protection.

• Dispose per institutional guidelines for chemical and biological reagents.

🧠 User Reports (Reddit Insights)

“SR9009 has practically no oral bioavailability because it was a test‑of‑test compound… not to be administered any other way than … injected” reddit.compubmed.ncbi.nlm.nih.gov+15reddit.com+15zellbio.eu+15
“I’ve also found it useful for regulating my circadian rhythm… more social… energy … not like a stimulant, more like wakefulness” targetmol.com+4reddit.com+4reddit.com+4